Steinhoff D, Weber H, Mohr U, Boehme K
Toxicol Appl Pharmacol. 1983 Jun 30;69(2):161-9. doi: 10.1016/0041-008x(83)90296-x.
Amitrole was evaluated for carcinogenic potential in lifespan studies on Wistar rats, NMRI mice, and golden hamsters. At the start of the studies the animals were 6 weeks old. Amitrole was administered, mixed with pulverized chow, at dietary concentrations of 0, 1, 10, and 100 micrograms/g (ppm). Each treated group and control group consisted of 75 male and 75 female rats and mice and of 76 male and 76 female golden hamsters. Additional animals were used to evaluate the functional state of the thyroid. Somewhat lower body weights, slightly reduced survival times, and transient effects on thyroid function were observed in golden hamsters at 100 ppm. In mice, a slight increase in pituitary gland hyperemias was seen at 100 ppm; also an effect on thyroid function usually occurred at the same concentration. In rats, a very large number of cystic dilatations of follicles in the thyroid at 100 ppm and a dose-unrelated increase in hemorrhages and hyperemias in the pituitary gland were indicative of an effect of amitrole on these organs. The strongest effect of amitrole on thyroid function, as compared to golden hamsters and mice, was seen in rats at 100 ppm. At this concentration a highly increased number of thyroid and pituitary gland tumors was observed in rats. In golden hamsters and mice, no tumor induction was seen.
在对Wistar大鼠、NMRI小鼠和金黄地鼠进行的终生研究中，对杀草强的致癌潜力进行了评估。研究开始时，动物为6周龄。杀草强与粉碎的食物混合，以0、1、10和100微克/克（ppm）的膳食浓度给药。每个处理组和对照组由75只雄性和75只雌性大鼠和小鼠以及76只雄性和76只雌性金黄地鼠组成。额外的动物用于评估甲状腺的功能状态。在100 ppm的金黄地鼠中观察到体重略低、存活时间略有缩短以及对甲状腺功能的短暂影响。在小鼠中，在100 ppm时可见垂体充血略有增加；同样，在相同浓度下通常也会对甲状腺功能产生影响。在大鼠中，100 ppm时甲状腺中大量的卵泡囊性扩张以及垂体中与剂量无关的出血和充血增加表明杀草强对这些器官有影响。与金黄地鼠和小鼠相比，杀草强对甲状腺功能的最强影响在100 ppm的大鼠中可见。在此浓度下，在大鼠中观察到甲状腺和垂体肿瘤的数量大幅增加。在金黄地鼠和小鼠中，未观察到肿瘤诱导现象。
