Jacyk W K
Arch Dermatol Res. 1978 May 31;261(3):331-2. doi: 10.1007/BF00455303.
Cotton et al [1] comparing glucose-6-phosphate dehydrogenase (G-6-PD) activity in biopsies from patients with lichen planus (LP) with that in normal skin suggested that LP might be associated with a congenital abnormality of the enzyme in the skin. Ryan et al. [7] were unable to confirm these results. It is known that individuals with erythrocyte G-6-PD deficiency show a similar decrease of the enzyme in the skin [2] and that skin biopsies can be used to diagnose favizm [3]. The increased incidence of LP in the tropics [6, 8] coincides with the prevalence of erythrocyte G-6-PD deficiency in the same geographical region. The semi-quantitative method of Motulsky did not reveal any difference of erythrocyte G-6-PD activity between patients with LP and control subjects [5]. The present study reports the results obtained with a more sensitive method of erythrocyte G-6-PD determination in a group of Africans with LP. Thirty Nigerian patients with typical clinical picture of LP (23 men and 7 women), aged 15--45 were studied. Control 30 subjects were matched for age, sex and tribe and included persons suffering from scabies and mild pyogenic and superficial mycotic infections. The activity of the erythrocyte G-6-PD was determined at 37 degrees C using the WHO method [9]. Normal values for Northern Nigerians are 1200 +/- 234 mu/1010 red cells. The results (Fig. 1) show a decrease of the erythrocyte G-6-PD activity in patients with lichen planus (P less than 0.01). No relationship between erythrocyte G-6-PD activity and extensiveness, activity or age of onset of the skin lesions was found. The finding of decreased erythrocyte G-6-PD activities in patients with LP in an area where an increased incidence of this skin disease coincides with higher frequency of favizm might suggest a biochemical overlap between these two conditions. Holzmann et al [4] have suggested that the reverse situation of mutual exclusiveness exists between G-6-PD deficiency and psoriasis. In regions with high frequency of G-6-PD defiency psoriasis is uncommon.
科顿等人[1]比较了扁平苔藓（LP）患者活检组织与正常皮肤中葡萄糖-6-磷酸脱氢酶（G-6-PD）的活性，提示LP可能与皮肤中该酶的先天性异常有关。瑞安等人[7]未能证实这些结果。已知红细胞G-6-PD缺乏的个体皮肤中该酶也有类似程度的降低[2]，且皮肤活检可用于诊断蚕豆病[3]。热带地区LP发病率的增加[6,8]与同一地理区域红细胞G-6-PD缺乏的流行情况相符。莫图尔斯基的半定量方法未显示LP患者与对照受试者之间红细胞G-6-PD活性有任何差异[5]。本研究报告了用更灵敏的方法测定一组患LP的非洲人红细胞G-6-PD活性所获得的结果。研究了30名有典型LP临床表现的尼日利亚患者（23名男性和7名女性），年龄在15至45岁之间。30名对照受试者在年龄、性别和部落方面进行了匹配，包括患有疥疮、轻度化脓性和浅表真菌感染的人。采用世界卫生组织的方法[9]在37℃下测定红细胞G-6-PD的活性。尼日利亚北部人的正常值为1200±234μ/10¹⁰个红细胞。结果（图1）显示扁平苔藓患者红细胞G-6-PD活性降低（P＜0.01）。未发现红细胞G-6-PD活性与皮肤损害的范围、活性或发病年龄之间存在关联。在这种皮肤病发病率增加与蚕豆病较高频率相符的地区，LP患者红细胞G-6-PD活性降低这一发现可能提示这两种情况之间存在生化重叠。霍尔兹曼等人[4]曾提出G-6-PD缺乏与银屑病之间存在相互排斥的相反情况。在G-6-PD缺乏高发地区，银屑病并不常见。
