Jakse G, Rauschmeier H, Rosmanith P, Hofstädter F
Urol Int. 1983;38(3):121-5. doi: 10.1159/000280875.
Carcinoembryonic antigen (CEA) is elevated in urine and/or serum of patients with transitional cell carcinoma (TCC) of the urinary bladder. A group of 26 patients with TCC of the urinary bladder were evaluated with regard to urine/serum CEA levels and CEA tissue content. CEA could be detected in normal, metaplastic and pre-neoplastic urothelium as well as tumor tissue. CEA was mainly localized on cell membranes, but with increasing tumor malignancy and infiltration a shift to cytoplasmatic localized CEA was noted. There was also a decrease in CEA content in the latter group. CEA urine levels were elevated above normal in more advanced tumor stages; however, the values varied greatly between individuals. All serum levels were within normal limits. No correlation could be established between urine/serum CEA levels and CEA tissue content.
癌胚抗原（CEA）在膀胱移行细胞癌（TCC）患者的尿液和/或血清中升高。对一组26例膀胱TCC患者的尿液/血清CEA水平和CEA组织含量进行了评估。在正常、化生和肿瘤前尿路上皮以及肿瘤组织中均可检测到CEA。CEA主要定位于细胞膜，但随着肿瘤恶性程度和浸润程度的增加，可观察到CEA向细胞质定位的转变。后一组中CEA含量也有所下降。在肿瘤晚期，CEA尿液水平高于正常；然而，个体之间的值差异很大。所有血清水平均在正常范围内。尿液/血清CEA水平与CEA组织含量之间未发现相关性。
