Alsabti E A, Saffo M H
Urol Int. 1979;34(5):387-92. doi: 10.1159/000280285.
Plasma carcinoembryonic antigen (CEA) levels were performed preoperatively by radioimmunoassay in 124 patients with histologically proved bladder carcinoma. The level of CEA was used to determine its prognostic value in patients with bladder cancer. The correlation of CEA levels with the stage of the disease, histology, and resectability was also studied. Values above 2.5 ng/ml were taken as abnormal. Active disease was associated with high CEA levels. All patients with CEA levels greater than 10 ng/ml died in less than 1 1/2 years, while all patients who survived 1 1/2-3 years had preoperative CEA levels less than 10 ng/ml. There was a prognostic significance for patients with transitional cell or squamous cell carcinoma. All patients with squamous cell carcinoma had CEA levels less than or equal to 10 ng/ml, and all patients with transitional carcinoma had preoperative CEA values greater than 10 ng/ml. A correlation between CEA levels and resectability of the primary tumor was found. This study indicates that, in bladder carcinoma patients, preoperative CEA levels greater than 10 ng/ml are of prognostic value, since all of these patients have died and all of the long-term survivors had levels of less than or equal to 10 ng/ml.
对124例经组织学证实为膀胱癌的患者术前采用放射免疫分析法检测血浆癌胚抗原（CEA）水平。CEA水平用于确定其在膀胱癌患者中的预后价值。还研究了CEA水平与疾病分期、组织学类型及可切除性的相关性。CEA值高于2.5 ng/ml被视为异常。疾病活动期与高CEA水平相关。所有CEA水平大于10 ng/ml的患者在不到1.5年的时间内死亡，而所有存活1.5 - 3年的患者术前CEA水平均低于10 ng/ml。对于移行细胞癌或鳞状细胞癌患者具有预后意义。所有鳞状细胞癌患者的CEA水平均小于或等于10 ng/ml，所有移行细胞癌患者术前CEA值均大于10 ng/ml。发现CEA水平与原发肿瘤的可切除性之间存在相关性。本研究表明，在膀胱癌患者中，术前CEA水平大于10 ng/ml具有预后价值，因为所有这些患者均已死亡，而所有长期存活者的CEA水平均小于或等于10 ng/ml。
