Ortonne J P, Claudy A, Alario A, Thivolet J
Arch Dermatol Res. 1978 Jul 28;262(2):143-51. doi: 10.1007/BF00455383.
Lymphocyte subpopulations were studied in 45 PUVA treated patients and in 45 controls matched for sex and age. The results demonstrate that, in vivo PUVA induces a decrease in the capacity of the E-Rosette formation by lymphocytes separated from the peripheral blood. However, the circulating lymphocytes count remains unchanged. Mitogen induced blastogenesis is not affected. No correlation is found between the decrease in the level of E-rosettes, the disease which motivated PUVA therapy, the energy in UVA and the number of irradiation. Electrical and/or chemical modifications on the cell surface of the lymphocytes during PUVA therapy are postulated to explain this phenomenon.
对45例接受补骨脂素加长波紫外线（PUVA）治疗的患者以及45例年龄和性别匹配的对照者的淋巴细胞亚群进行了研究。结果表明，体内PUVA可使从外周血分离出的淋巴细胞形成E花环的能力降低。然而，循环淋巴细胞计数保持不变。有丝分裂原诱导的细胞增殖不受影响。E花环水平的降低、促使进行PUVA治疗的疾病、紫外线A（UVA）的能量以及照射次数之间未发现相关性。推测PUVA治疗期间淋巴细胞细胞表面的电学和/或化学修饰可解释这一现象。
