Lischka G
Arch Dermatol Res. 1979 Jun 25;265(2):213-8. doi: 10.1007/BF00407887.
The lymphocyte proliferation of 15 psoriatic patients was sutdied after stimulation with tuberculin, trichophytin, varidase, concanavalin A (Con A), and pokeweek mitogen (PMW) during the first and the eighth PUVA treatment, 2 h after oral intake of 8-methoxypsoralen (8-MOP), immediately after UVA-irradiation, and 24 h later. There was a significant decrease of the lymphocyte proliferation, after stimulation with Con A (P less than 0.05), trichophytin (P less than 0.01) and varidase (P less than 0.05), not with PWM and tuberculin, during the first PUVA treatment by 8-MOP alone. This decrease was not significantly changed by the following UVA irradiation and could not be demonstrated after 24 h. No dark effect of 8-MOP on the lymphocyte proliferation could be seen during the eighth treatment. 8-MOP seems to influence lymphocyte proliferation in the dark by interfering with the cell surface, not with the nucleus. The disappearence of this effect during PUVA therapy could be explained by a modification on the surface structure of lymphocytes.
在15例银屑病患者接受第一次和第八次补骨脂素加长波紫外线（PUVA）治疗期间，于口服8 - 甲氧基补骨脂素（8 - MOP）后2小时、长波紫外线（UVA）照射后即刻以及24小时后，分别用结核菌素、癣菌素、溶菌酶、刀豆蛋白A（Con A）和商陆有丝分裂原（PMW）刺激，观察淋巴细胞增殖情况。在第一次仅用8 - MOP进行PUVA治疗时，用Con A（P＜0.05）、癣菌素（P＜0.01）和溶菌酶（P＜0.05）刺激后淋巴细胞增殖显著下降，而用PWM和结核菌素刺激时未出现这种情况。随后的UVA照射并未使这种下降有显著改变，24小时后也未观察到这种情况。在第八次治疗期间未见到8 - MOP对淋巴细胞增殖的暗效应。8 - MOP似乎通过干扰细胞表面而非细胞核来影响暗处的淋巴细胞增殖。PUVA治疗期间这种效应的消失可通过淋巴细胞表面结构的改变来解释。
