Di Francesco C, Meier C, Schaltegger H, Krebs A
Arch Dermatol Res. 1978 Jul 28;262(2):177-84. doi: 10.1007/BF00455388.
This study was aimed at investigating the role of the nerves in the pathomechanism of psoriasis. The structure of skin nerves of 10 patients with active psoriasis and of 6 healthy control persons has been studied by means of the microscope and the electron-microscope. Eight of the patients were subjected to punch biopsies of psoritatic plaques as well as clinically normal skin. No qualitative difference could be detected between the skin nerves from psoriatic patients and from healthy persons. Quantitative investigations showed that the density of myelinated and unmyelinated axons in psoriatic skin nerves did not differ from that in normal skin nerves in a statistically significant degree. This means that the ratio of myelinated to unmyelinated axons was alike in both normal and psoriatic skin nerves. Also the diameter distribution of myelinated and unmyelinated axons was similar. The difference in the degree of myelinisation and in the myelinperiodicity between psoriatic and control skin was not statistically significant. Neither qualitative nor quantitative morphologic alterations in the skin nerves of psoriatic persons could be detected.
本研究旨在探讨神经在银屑病发病机制中的作用。通过显微镜和电子显微镜对10例活动性银屑病患者及6名健康对照者的皮肤神经结构进行了研究。其中8例患者接受了银屑病斑块及临床正常皮肤的打孔活检。银屑病患者与健康人的皮肤神经在定性方面未检测到差异。定量研究表明，银屑病皮肤神经中有髓和无髓轴突的密度与正常皮肤神经相比，在统计学上无显著差异。这意味着正常和银屑病皮肤神经中有髓与无髓轴突的比例相似。有髓和无髓轴突的直径分布也相似。银屑病皮肤与对照皮肤在髓鞘化程度和髓鞘周期方面的差异无统计学意义。未检测到银屑病患者皮肤神经在定性或定量形态学上的改变。
