Soboleva V D, Lozovskaia L S, Mitchenko A F
Vopr Virusol. 1983 Mar-Apr(2):207-10.
The blood specimens from 22 children with rheumatoid arthritis, 57 children with other chronic diseases and 30 apparently normal children were tested for the presence of Coxsackie A and B, adeno, and rubella viruses by the method of co-cultivation of patient's lymphocytes with continuous HEp-2 cell culture. Children with chronic diseases were found to have viremia much more frequently than normal children. The frequency of finding of different viruses in patients with rheumatoid arthritis (86.4%) significantly exceeded that in healthy children (20%). These patients had rubella and adeno 5 viruses in their blood more frequently than children in the other groups under study. Repeated examinations of 14 patients with rheumatoid arthritis at intervals of 1 year or longer revealed in 11 of them the same viruses as those identified in initial examinations. Persistence of some viruses in patients with rheumatoid arthritis is discussed.
采用患者淋巴细胞与连续传代的HEp-2细胞共培养的方法，对22例类风湿性关节炎患儿、57例患有其他慢性病的患儿以及30例看似正常的儿童的血液标本进行检测，以确定是否存在柯萨奇A和B病毒、腺病毒和风疹病毒。结果发现，患有慢性病的儿童出现病毒血症的频率比正常儿童高得多。类风湿性关节炎患者中发现不同病毒的频率（86.4%）显著高于健康儿童（20%）。这些患者血液中风疹病毒和腺病毒5型的出现频率高于其他受试组的儿童。对14例类风湿性关节炎患者间隔1年或更长时间进行重复检测，结果显示其中11例患者体内的病毒与初次检测时相同。文中讨论了类风湿性关节炎患者体内某些病毒的持续存在情况。
