Williams G T, Johnson S A, Dieppe P A, Huskisson E C
Ann Rheum Dis. 1978 Aug;37(4):366-9. doi: 10.1136/ard.37.4.366.
Of 60 patients with rheumatoid arthritis treated with levamisole 35% showed a persistent decrease in neutrophil counts from pre-treatment levels and 6 (10%) develped severe neutropenia of less than 1.0 X 10(9)/1. One of these neutropenic patients recoverd without stopping therapy and the other 5 patients recovered rapidly when the drug was withdrawn. In some patients neutropenia recurred on reinstitution of levamisole.
在60例接受左旋咪唑治疗的类风湿性关节炎患者中,35%的患者中性粒细胞计数持续低于治疗前水平,6例(10%)出现严重中性粒细胞减少,低于1.0×10⁹/L。其中1例中性粒细胞减少患者未停药即康复,另外5例患者停药后迅速康复。部分患者重新使用左旋咪唑后中性粒细胞减少复发。