Shiraishi M, Matsuo K, Takebayashi S
Acta Pathol Jpn. 1983 Mar;33(2):265-73. doi: 10.1111/j.1440-1827.1983.tb01416.x.
Single and repeated restrained stresses in rats were conducted as a model for evaluating sequential changes of gastric submucosal arteries evoked by stressful stimuli with an emphasis on medial alterations. By single restrained stress, three distinct acute changes of the media were found after a short time of the stress-withdrawal; (1) focal cytoplasmic necrosis, (2) fibrin insudation, and (3) leukocyte migration. These acute lesions were readily healed within 20 days without cellular increase or fibrous thickening of the intima. When the stress was repeated over a long period of time, medial smooth muscle cells showed marked degenerative changes ("atrophy with moth-eaten structure") with an increase of granular cell debris and basement membrane-like materials. The results suggest that angiopathic effects of stresses may be attributed to the unsuited responsiveness of small artery to vasospasm and its sequential hemodynamic derangements.
以大鼠的单次和重复束缚应激作为模型，用于评估应激刺激引起的胃黏膜下动脉的系列变化，重点关注中膜改变。通过单次束缚应激，在应激撤除后的短时间内发现中膜有三种明显的急性变化：(1) 局灶性细胞质坏死，(2) 纤维蛋白渗出，以及(3) 白细胞迁移。这些急性病变在20天内很容易愈合，内膜无细胞增多或纤维增厚。当长时间重复应激时，中膜平滑肌细胞显示出明显的退行性变化（“虫蚀样萎缩结构”），颗粒细胞碎片和基底膜样物质增加。结果表明，应激的血管病变作用可能归因于小动脉对血管痉挛的不适当反应及其后续的血流动力学紊乱。
