胺碘酮、哌克昔林和苄普地尔对慢性心脏传导阻滞未麻醉犬心律的比较作用。
Comparative effects of amiodarone, perhexiline and bepridil on the cardiac rhythms of the unanesthetized dog in chronic heart block.
作者信息
Boucher M, Duchene-Marullaz D
出版信息
Arch Int Pharmacodyn Ther. 1978 May;233(1):65-75.
PMID:686908
Abstract
The effects of amiodarone, perhexiline and bepridil, which decrease effort cardioacceleration although they have no adrenergic beta blocking properties, were studied in the unanesthetized dog in chronic heart block. All three products decreased atrial rate in a durable way after an initial phase of tachycardia. Amiodarone had no depressant effect on idioventricular rate; however, this was significantly slowed by the other two compounds.
摘要
在慢性心脏传导阻滞的未麻醉犬中，研究了胺碘酮、哌克昔林和苄普地尔的作用，这些药物虽无肾上腺素能β受体阻滞特性，但能降低用力时的心率加速。在心动过速的初始阶段后，所有这三种药物均能持久地降低心房率。胺碘酮对心室自主节律无抑制作用；然而，其他两种化合物可使其显著减慢。
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