[Effect of the preparations amiodarone, pexid and CERM-1978 on sinus rhythm and atrioventricular conduction in unanesthetized dogs].

The author examined the influence of Amiodarone, Perexiline maliate (Pexid) and the preparation CERM-1978 (Bepiridil) on the sinus rhythm and atrioventriular conduction of trained dogs with preliminary implanted electrodes for electrostimulation of the right atrium under the conditions of chronic experiment. The three preparations in doses of 2,5 and 5 mg/kg of body weight prolonged the refractory period of the atrioventricular zone, estimated by the method of "the maximal atrioventricular frequency". The br dicaric effect was also present, more manifested in a dose of 2.5 mg/kg of body weight. The established negative chrono- and dromotropic action had their maximum 15 minutes after the administration and lasted more than 2 hours.