Ginsburg R
Am J Cardiol. 1983 Jul 20;52(2):61A-66A. doi: 10.1016/0002-9149(83)90178-9.
Ring segments from coronary arteries from recipient hearts of patients receiving cardiac transplants were prepared and mounted in an organ bath. Spontaneous contractile activity, factors that affect basal tone, agonist-induced contractile responses, regional receptor distribution, activity of cardioactive drugs, and species differences were studied. Agents that mediate contraction include histamine, acetylcholine, norepinephrine, potassium and some prostaglandins. Calcium-entry blockers, nitrates and beta-adrenergic agonists caused relaxation. Major species differences exist in coronary vascular pharmacology. Ring segments from human epicardial coronary arteries are suitable for pharmacologic studies, and because of species differences, they offer an ideal model for investigating the pharmacology of the human coronary circulation.
取自接受心脏移植患者供体心脏冠状动脉的环状节段被制备出来并安装在器官浴槽中。研究了自发收缩活动、影响基础张力的因素、激动剂诱导的收缩反应、局部受体分布、心血管活性药物的活性以及种属差异。介导收缩的物质包括组胺、乙酰胆碱、去甲肾上腺素、钾离子和一些前列腺素。钙通道阻滞剂、硝酸盐和β肾上腺素能激动剂可引起舒张。冠状动脉药理学存在主要的种属差异。来自人类心外膜冠状动脉的环状节段适用于药理学研究，并且由于种属差异，它们为研究人类冠状动脉循环的药理学提供了一个理想的模型。
