Ginsburg R, Bristow M R, Harrison D C, Stinson E B
Chest. 1980 Jul;78(1 Suppl):180-6.
We studied the basic mechanisms involved in human coronary artery smooth-muscle contraction in an attempt to gain insight into the pathophysiology and pathopharmacology of coronary spasm. coronary arteries were obtained from recipient hearts of patients receiving cardiac transplantation at Stanford University. Coronary ring segments were studied in an organ bath using standard Tyrode's solution. Observation included characterizations of spontaneous contractile activity, factors affecting basal tone, type of agonist-induced contractile respnse, receptor distribution, activity of cardioactive drugs, and species differences. Agents mediating contraction included histamine, acetylcholine, norepinephrine, potassium, and prostaglandins. Because of recent clinical interest in calcium antagonists, diltiazem was studied extensively. Diltiazem demonstrated noncompetitive antagonism to the effects of several agonists and competitive antagonism to calcium. The exact cause and mechanism of coronary spasm is still unknown, but we have identified new areas for future investigation.
我们研究了人类冠状动脉平滑肌收缩所涉及的基本机制，以期深入了解冠状动脉痉挛的病理生理学和病理药理学。冠状动脉取自斯坦福大学接受心脏移植患者的供体心脏。在器官浴槽中使用标准台氏液对冠状动脉环段进行研究。观察内容包括自发收缩活动的特征、影响基础张力的因素、激动剂诱导的收缩反应类型、受体分布、心血管活性药物的活性以及种属差异。介导收缩的物质包括组胺、乙酰胆碱、去甲肾上腺素、钾和前列腺素。由于近期临床对钙拮抗剂感兴趣，故对地尔硫䓬进行了广泛研究。地尔硫䓬对几种激动剂的作用表现为非竞争性拮抗，对钙表现为竞争性拮抗。冠状动脉痉挛的确切病因和机制仍不清楚，但我们已经确定了未来研究的新领域。
