Petitti D B, Klatsky A L
Am J Cardiol. 1983 Aug;52(3):297-8. doi: 10.1016/0002-9149(83)90126-1.
To study the factors associated with malignant hypertension in young women, we reviewed the medical records of all women aged 15 to 44 years who were hospitalized in any of 15 affiliated hospitals from 1971 to 1980 with malignant hypertension. There were 15 new patients in this period, an incidence of 0.5 per 100,000 women of these ages per year. Four women had underlying renal disease. All of the remaining 11 used oral contraceptives, smoked cigarettes, or both. Nine were white, and 6 women had normal blood pressure in the 24 months before hospitalization. These findings support a relation of oral contraceptive use and cigarette smoking to an increased risk of malignant hypertension in young women.
为研究年轻女性恶性高血压的相关因素，我们回顾了1971年至1980年间在15家附属医院中因恶性高血压住院的所有15至44岁女性的病历。在此期间有15例新患者，这些年龄段的女性每年发病率为十万分之0.5。4名女性有潜在肾脏疾病。其余11名女性均使用口服避孕药、吸烟或两者兼而有之。9名是白人，6名女性在住院前24个月血压正常。这些发现支持口服避孕药和吸烟与年轻女性恶性高血压风险增加之间存在关联。
