10-脱氮氨基蝶呤用于晚期结直肠癌患者的II期试验。
Phase II trial of 10-deaza-aminopterin in patients with advanced colorectal cancer.
作者信息
Cheng E W, Currie V E, Yagoda A
出版信息
Am J Clin Oncol. 1983 Aug;6(4):469-71. doi: 10.1097/00000421-198308000-00013.
Abstract
Twenty-two patients with advanced colorectal cancer were treated with 10-deaza-aminopterin given intravenously twice weekly for four doses beginning at 15 mg/m2. Twelve patients had no prior chemotherapy. Dose-limiting toxicity was mucositis. Tumor regression was not seen in any patient.
摘要
22例晚期结直肠癌患者接受了10-脱氮氨基蝶呤治疗，静脉注射，每周两次，共四剂，起始剂量为15mg/m²。12例患者此前未接受过化疗。剂量限制性毒性为粘膜炎。所有患者均未出现肿瘤消退。
Zotero 插件