甲氨蝶呤与10-脱氮氨基蝶呤治疗类风湿关节炎的对照试验。
Controlled trial of methotrexate versus 10-deazaaminopterin in the treatment of rheumatoid arthritis.
作者信息
Alarcón G S, Castañeda O, Nair M G, Ferrándiz M, Koopman W J, Krumdieck C L
机构信息
Department of Medicine, University of Alabama, Birmingham.
出版信息
Ann Rheum Dis. 1992 May;51(5):600-3. doi: 10.1136/ard.51.5.600.
Abstract
A 15 week double blind controlled trial of methotrexate and 10-deazaaminopterin for the treatment of rheumatoid arthritis (RA) was performed in 26 patients. Significant improvement in all measured clinical parameters was observed in the two patient groups. The drugs were well tolerated; only one patient (10-deazaaminopterin) withdrew from the study because of side effects. It is concluded that, in the context of this relatively short clinical trial, 10-deazaaminopterin is at least as beneficial as methotrexate in the treatment of RA.
摘要
对26例类风湿性关节炎（RA）患者进行了一项为期15周的甲氨蝶呤和10-脱氮氨基蝶呤治疗的双盲对照试验。两个患者组在所有测量的临床参数上均有显著改善。药物耐受性良好；只有一名患者（10-脱氮氨基蝶呤组）因副作用退出研究。得出的结论是，在这项相对较短的临床试验中，10-脱氮氨基蝶呤在治疗RA方面至少与甲氨蝶呤一样有效。
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