Wright W E, Peters J M, Mack T M
Am J Ind Med. 1983;4(4):577-81. doi: 10.1002/ajim.4700040411.
Chemists with cancer were interviewed to generate hypotheses that might explain an apparent excess of malignant melanoma in chemists in Los Angeles County (LAC). The chemists were identified by the LAC Cancer Surveillance Program, a population-based cancer registry. Interviews that included information on work history and exposure to specific chemicals were conducted by telephone. Chemists with melanoma were found to be better educated than chemists with other cancers and they reported more work with organic chemicals. They also cited more exposure to multiple chemicals, solvents, plastics, pesticides, benzoyl peroxide, and ionizing radiation. Although differences in educational level may account for the differences in exposure reported by cases and controls, the hypotheses that specific chemical exposures are related to melanoma occurrence are plausible and deserve further study. We also suggest that this method of generating hypotheses about cancer causes using cases identified from registries could be used more extensively.
对患癌化学家进行了访谈，以提出可能解释洛杉矶县（LAC）化学家中恶性黑色素瘤明显过多现象的假设。这些化学家是通过LAC癌症监测项目（一个基于人群的癌症登记处）确定的。通过电话进行了访谈，内容包括工作经历以及接触特定化学物质的情况。发现患黑色素瘤的化学家比患其他癌症的化学家受教育程度更高，并且他们报告称更多地从事有机化学物质方面的工作。他们还提到更多地接触多种化学物质、溶剂、塑料、农药、过氧化苯甲酰和电离辐射。尽管教育水平的差异可能解释了病例组和对照组报告的接触情况差异，但特定化学物质接触与黑色素瘤发生有关的假设似乎合理，值得进一步研究。我们还建议，这种利用登记处确定的病例来生成关于癌症病因假设的方法可以更广泛地使用。
