McLaughlin M K, Quinn P M, Farnham J S
Am J Obstet Gynecol. 1983 Jul 15;146(6):633-8. doi: 10.1016/0002-9378(83)91004-9.
Threshold concentrations for angiotensin II and barium chloride were determined in the perfused hind limb of the nonpregnant, pseudopregnant, and pregnant rabbit. The threshold concentration for these vasoconstrictors was defined as the amount of drug per milliliter of hind limb blood flow which would increase hind limb blood pressure by 4 mm Hg. There was no difference in the mean angiotensin II threshold concentration between the nonpregnant and pseudopregnant rabbits. The angiotensin II dose for the pregnant rabbits was double that of the first two groups. There was no significant difference in the mean barium chloride threshold concentration between the three groups. This difference in the pregnant angiotensin II threshold concentration with no difference in barium chloride threshold concentration indicates a change in vascular sensitivity which is dependent upon a specific angiotensin II-receptor interaction and is not inherent in the contractile response of the vessel, nor is it mimicked by pseudopregnancy.
在未孕、假孕和孕兔的灌注后肢中测定了血管紧张素 II 和氯化钡的阈浓度。这些血管收缩剂的阈浓度定义为每毫升后肢血流中能使后肢血压升高 4 mmHg 的药物量。未孕兔和假孕兔的血管紧张素 II 平均阈浓度没有差异。孕兔的血管紧张素 II 剂量是前两组的两倍。三组之间的氯化钡平均阈浓度没有显著差异。孕兔血管紧张素 II 阈浓度的这种差异以及氯化钡阈浓度无差异表明血管敏感性发生了变化，这种变化依赖于特定的血管紧张素 II 受体相互作用，并非血管收缩反应所固有，假孕也不能模拟这种变化。
