应用于全静脉麻醉的药代动力学。理论思考。
Pharmacokinetics as applied to total intravenous anaesthesia. Theoretical considerations.
作者信息
Schwilden H, Schüttler J, Stoekel H
出版信息
Anaesthesia. 1983 Jul;38 Suppl:51-2. doi: 10.1111/j.1365-2044.1983.tb15178.x.
Abstract
Some theoretical considerations of pharmacokinetics as applied to total intravenous anaesthesia are discussed. The problem is the need to achieve a concentration within the therapeutic range at the receptor site. The use of linear compartment models, and of the superposition principle within these models, is discussed.
摘要
讨论了药代动力学在全静脉麻醉中的一些理论考量。问题在于需要在受体部位达到治疗范围内的浓度。文中讨论了线性房室模型的使用以及这些模型中的叠加原理。
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