Lecrubier C, Conard J, Horellou M H, Samama M
Ann Biol Clin (Paris). 1983;41(1):17-21.
136 control subjects and 131 patients, consisting of 23 diabetics with severe retinopathy, 43 cases of valvular disease with or without a prosthesis and 65 patients who had a cerebral vascular accident, were systematically investigated for the presence of spontaneous platelet aggregation 31 controls and 108 patients were examined for reversible circulating platelet aggregates using the technique of Wu and Hoak. Frank spontaneous aggregation was observed in 6 of the 136 control subjects, 6 of the 21 patients without a valvular prosthesis and 2 of the 22 patients with such a valvular prosthesis and 2 of the 22 patients with such a prosthesis, only 1 of the 23 diabetics and 5 of the 65 patients with old or recent cerebral vascular accidents. The incidence of spontaneous aggregation seems to be directly related to certain operative conditions: the type of machine used, the number of platelets, and to the treatment administered, the Wu and Hoak test. No statistically significant correlation was demonstrated between spontaneous aggregation and the Wu and Hoak test. The exact clinical significance of the presence of spontaneous aggregation is still disputed. However, the examination for this abnormality should be routine as its presence can alter the interpretation of the results of aggregation induced by various aggregating agents.
对136名对照受试者和131名患者进行了系统研究，以检测其是否存在自发性血小板聚集。这些患者包括23名患有严重视网膜病变的糖尿病患者、43例有或无人工瓣膜的瓣膜病患者以及65名发生过脑血管意外的患者。采用吴和霍克技术对31名对照者和108名患者检测了可逆性循环血小板聚集体。在136名对照受试者中有6人、在21名无人工瓣膜的患者中有6人、在22名有这种人工瓣膜的患者中有2人观察到明显的自发性聚集。在23名糖尿病患者中只有1人，在65名有陈旧性或近期脑血管意外的患者中有5人观察到明显的自发性聚集。自发性聚集的发生率似乎与某些手术条件直接相关：所用机器的类型、血小板数量以及所给予的治疗即吴和霍克试验。未证明自发性聚集与吴和霍克试验之间存在统计学上的显著相关性。自发性聚集存在的确切临床意义仍存在争议。然而，对这种异常情况的检查应作为常规检查，因为其存在可能会改变对各种聚集剂诱导的聚集结果的解释。
