Combie J D, Nugent T E, Tobin T
Am J Vet Res. 1983 May;44(5):870-4.
Morphine could be detected in horses dosed with 0.1 mg of drug/kg of body weight for up to 48 hours in blood and 144 hours in urine. This dose of morphine elicited no observable effects and is a suggested analgesic dose. Computer analysis revealed that a 3-compartment open system was the best fitting model with a serum half life (t1/2(beta)) of 87.9 minutes and a urine t1/2(beta) of 101.1 minutes. Binding to equine serum proteins was linear over a drug concentration range of 3.88 X 10(-5)M to 3.50 X 10(-8)M and averaged 31.6%. In RBC-partitioning experiments, 78.1% of the drug was found in the plasma fraction. The data indicated that a horse should not be given morphine closer than 1 week before a race.
给体重每千克注射0.1毫克药物的马匹用药后，血液中吗啡可在长达48小时内检测到，尿液中可在144小时内检测到。该剂量的吗啡未引发可观察到的效应，是建议的镇痛剂量。计算机分析显示，三室开放系统是最佳拟合模型，血清半衰期（t1/2(beta)）为87.9分钟，尿液t1/2(beta)为101.1分钟。在3.88×10(-5)M至3.50×10(-8)M的药物浓度范围内，与马血清蛋白的结合呈线性，平均为31.6%。在红细胞分配实验中，78.1%的药物存在于血浆部分。数据表明，赛马前1周内不应给马注射吗啡。
