Moshé S L, Albala B J
Ann Neurol. 1983 May;13(5):552-7. doi: 10.1002/ana.410130514.
The ability of the central nervous system to suppress recurrent seizures as a function of age was determined in rats. Eight electrical stimulations were delivered to the amygdala at 2-minute intervals in adult and suckling rats that were previously kindled from the left amygdala. During this 16-minute period, prolonged and severe convulsions were repeatedly elicited in the 16-day-old rat pups, whereas convulsions were not always elicited in adult rats. The results suggest that immature rats are more prone to develop status epilepticus than adult rats. Subsequently, the rat pups and implanted but not stimulated littermates were allowed to grow. At maturity, all the surviving animals were kindled from the contralateral (right) amygdala. The previously kindled rats developed seizures significantly faster than did their littermates. However, their respective abilities to suppress recurrent seizures did not differ at 150 and 210 days of age, being similar to the seizure suppression abilities of naive controls and significantly greater than those evidenced in infancy. We conclude that the propensity to develop single seizures in adulthood is directly related to infant seizure history, whereas the ability to suppress multiple seizures is a dynamic process that is modified by age, being minimal early in life and enhanced with maturation independently of history of infantile convulsions.
在大鼠中确定了中枢神经系统抑制复发性癫痫发作的能力随年龄的变化情况。对先前由左侧杏仁核点燃的成年大鼠和乳鼠，每隔2分钟对杏仁核进行8次电刺激。在这16分钟期间，16日龄的幼鼠反复引发了长时间的严重惊厥，而成年大鼠并非总能引发惊厥。结果表明，未成熟大鼠比成年大鼠更容易发展为癫痫持续状态。随后，让幼鼠和植入但未受刺激的同窝幼鼠生长。成熟时，所有存活的动物都由对侧（右侧）杏仁核点燃。先前点燃的大鼠比其同窝幼鼠发作癫痫的速度明显更快。然而，它们各自抑制复发性癫痫发作的能力在150日龄和210日龄时并无差异，与未经历过癫痫发作的对照组的癫痫抑制能力相似，且明显高于婴儿期的表现。我们得出结论，成年期发生单次癫痫发作的倾向与婴儿期癫痫发作史直接相关，而抑制多次癫痫发作的能力是一个动态过程，会随年龄而改变，在生命早期最小，且随成熟而增强，与婴儿期惊厥史无关。
