Bolin S, Nilsson E, Sjödahl R
Ann Surg. 1983 Aug;198(2):151-8. doi: 10.1097/00000658-198308000-00007.
Twenty-seven carcinomas of the colon or rectum are presented which could retrospectively be measured on radiographs at two separate occasions. The mean diameter of the tumors at first and second investigations was 35 mm (10-90 mm) and 65 mm (30-110 mm), respectively, and the median interval between these examinations was 11 months (4-91 months). The median linear growth rate was 0.083 mm/day (0.008-0.262 mm/day). The median time for doubling of tumor volume was 130 days (53-1570 days), assuming a three-dimensional pattern of tumor growth. A significant correlation between poor differentiation and high linear growth rate (greater than or equal to 0.1 mm/day) was found. It is suggested that the high growth rate observed in this investigation in comparison with some previous studies may be due to the large size of the tumors and, hence, to their great risk of being malignant already at the first examination.
本文呈现了27例结肠或直肠癌病例，这些病例可在回顾性研究中于两个不同时间点通过X光片进行测量。首次和第二次检查时肿瘤的平均直径分别为35毫米（10 - 90毫米）和65毫米（30 - 110毫米），两次检查之间的中位间隔时间为11个月（4 - 91个月）。中位线性生长速率为0.083毫米/天（0.008 - 0.262毫米/天）。假设肿瘤呈三维生长模式，肿瘤体积翻倍的中位时间为130天（53 - 1570天）。研究发现，低分化与高线生长速率（大于或等于0.1毫米/天）之间存在显著相关性。有人提出，与之前的一些研究相比，本研究中观察到的高生长速率可能是由于肿瘤体积较大，因此在首次检查时就已经具有较高的恶性风险。
