Handa M, Kondo K, Saruta T
Arch Int Pharmacodyn Ther. 1983 Mar;262(1):124-31.
The effects of four different diuretics, hydroflumethiazide, furosemide, piretanide and potassium canrenoate on the vascular responses to norepinephrine and potassium chloride in the perfused rat mesenteric vascular bed have been studied. Furosemide or piretanide in the perfusate inhibited the vascular response to norepinephrine in a dose-related manner, while the vascular contraction induced by potassium chloride was not affected by these substances. In contrast to furosemide and piretanide, potassium canrenoate inhibited vascular responses to both norepinephrine and potassium ions. Hydroflumethiazide did not induce any change in the vascular response to norepinephrine or to potassium chloride. From these results, it is suggested that furosemide, piretanide and potassium canrenoate, but not hydroflumethiazide have direct vascular actions independent from their renal actions which may contribute to their antihypertensive effects.
研究了四种不同利尿剂，即氢氟噻嗪、呋塞米、吡咯他尼和坎利酸钾对灌注大鼠肠系膜血管床中去甲肾上腺素和氯化钾血管反应的影响。灌注液中的呋塞米或吡咯他尼以剂量相关的方式抑制对去甲肾上腺素的血管反应，而氯化钾诱导的血管收缩不受这些物质影响。与呋塞米和吡咯他尼相反，坎利酸钾抑制对去甲肾上腺素和钾离子的血管反应。氢氟噻嗪未引起对去甲肾上腺素或氯化钾血管反应的任何变化。从这些结果表明，呋塞米、吡咯他尼和坎利酸钾，但不是氢氟噻嗪具有独立于其肾脏作用的直接血管作用，这可能有助于它们的降压作用。
