Nelson K R, Brenner R P, de la Paz D
Arch Neurol. 1983 Aug;40(8):473-6. doi: 10.1001/archneur.1983.04210070013005.
Clinical features of 40 patients with midline spikes on EEG were compared with those of age- and sex-matched controls. Seizure incidence was significantly greater in the study group than in the controls (85% v 45%). Tonic-clonic seizures were the most frequent type. Eighteen patients from the study group had additional focal or generalized epileptiform abnormalities. This subgroup had a significantly greater incidence of seizures than patients with only midline spikes (100% v 73%). Midline spikes are more common in children and markedly activated with sleep. They must be distinguished from normal sleep transients.
对40例脑电图显示中线棘波患者的临床特征与年龄和性别匹配的对照组进行了比较。研究组的癫痫发作发生率显著高于对照组（85%对45%）。强直阵挛性发作是最常见的类型。研究组中有18例患者还存在额外的局灶性或全身性癫痫样异常。该亚组的癫痫发作发生率显著高于仅存在中线棘波的患者（100%对73%）。中线棘波在儿童中更常见，且在睡眠时明显激活。必须将它们与正常睡眠瞬变区分开来。
