Ehle A, Co S, Jones M G
Arch Neurol. 1981 Jun;38(6):355-7. doi: 10.1001/archneur.1981.00510060057008.
Twenty-one children had interictal EEGs showing spikes located at the Fz, Cz, and Pz electrodes; their EEGs were compared with those of age-matched children referred to our laboratory (group 1, 63 children) and children with C3 and C4 spikes (group 2, 41 children). Midline spikes correlated well with a history of seizures (91% vs 73% in group 1 and 76% in group 2) and neurologic abnormality (38% vs 29% in group 1 and 22% in group 2). No patient had progressive neurologic disease or brain tumor. There are two different possible mechanisms in the genesis of midline spikes. In the majority of children, midline spikes may represent generalized epileptiform abnormalities; in a small subgroup, they may be analogous to C3 and C4 spikes and be generated by a cortical epileptogenic focus.
21名儿童的发作间期脑电图显示棘波位于Fz、Cz和Pz电极处；将他们的脑电图与转诊至我们实验室的年龄匹配儿童（第1组，63名儿童）以及有C3和C4棘波的儿童（第2组，41名儿童）的脑电图进行比较。中线棘波与癫痫发作史（第1组为91%，第2组为73%，第2组为76%）和神经学异常（第1组为38%，第2组为29%，第2组为22%）密切相关。没有患者患有进行性神经疾病或脑肿瘤。中线棘波的产生有两种不同的可能机制。在大多数儿童中，中线棘波可能代表全身性癫痫样异常；在一小部分亚组中，它们可能类似于C3和C4棘波，并由皮质癫痫病灶产生。
