Hirst L W, Smiddy W E, De Juan E
Aust J Ophthalmol. 1983 May;11(2):113-8.
The current indications for and method of application of tissue adhesive are described. A method for an expanded utilisation of tissue adhesive is discussed. To study the effect of the introduction of tissue adhesive to The Wilmer Institute in 1974, the records of 104 consecutive non-traumatic corneal perforations or descemetoceles admitted to The Wilmer Institute from 1960 to 1980 were assessed retrospectively with follow-up being obtained from records or from referral physicians for 87 of these perforations. Forty-nine percent of the cases were caused by bacterial corneal ulcers, 13% by exposure, 12% by chemical burns, 6% by fungal keratitis, 5% by herpes simplex keratitis, and 15% were undiagnosed. Since the introduction of tissue adhesive in 1974, there has been an apparent trend towards a lower enucleation rate (6%) in the tissue adhesive treated group compared with 19% in perforations treated by other therapies.
本文描述了组织黏合剂目前的应用指征及方法。探讨了一种扩大组织黏合剂应用范围的方法。为研究1974年组织黏合剂引入威尔默眼科研究所后的效果，我们对1960年至1980年期间连续收治于该研究所的104例非创伤性角膜穿孔或后弹力层膨出病例的记录进行了回顾性评估，其中87例穿孔的随访信息通过病历记录或转诊医生获得。49%的病例由细菌性角膜溃疡引起，13%由暴露所致，12%由化学烧伤引起，6%由真菌性角膜炎引起，5%由单纯疱疹性角膜炎引起，15%病因未明。自1974年引入组织黏合剂以来，与采用其他疗法治疗的穿孔病例（19%）相比，组织黏合剂治疗组的眼球摘除率明显呈下降趋势（6%）。
