Hirst L W, Smiddy W E, Stark W J
Ophthalmology. 1982 Jun;89(6):630-5.
One hundred four nontraumatic corneal perforations or descemetoceles in patients admitted to the Wilmer Institute from 1960 to 1980 were studied retrospectively, with follow-up data obtained from records or from referral physicians for 87 of these perforations. Forty-nine percent of the cases were caused by bacterial corneal ulcers, 13% by exposure, 12% by chemical burns, 6% by fungal keratitis, 5% by herpes simplex keratitis, and 15% were undiagnosed. Since the start of tissue adhesive use at the Wilmer Institute in 1974, there has been an apparent trend towards a lower enucleation rate (6%) in corneal perforations treated with tissue adhesive as compared to 19% in perforations treated by other therapies, although the cases may not be entirely comparable. An improved visual result of 20/200 or better was achieved in 29% of patients treated with tissue adhesive as compared to 19% with other treatment.
对1960年至1980年收治于威尔默眼科研究所的104例非创伤性角膜穿孔或后弹力层膨出患者进行了回顾性研究，其中87例穿孔患者的随访数据来自病历记录或转诊医生。49%的病例由细菌性角膜溃疡引起，13%由暴露所致，12%由化学烧伤引起，6%由真菌性角膜炎引起，5%由单纯疱疹性角膜炎引起，15%病因未明。自1974年威尔默眼科研究所开始使用组织粘合剂以来，与采用其他疗法治疗的穿孔病例（19%）相比，使用组织粘合剂治疗的角膜穿孔患者的眼球摘除率有明显下降趋势（6%），尽管这些病例可能不完全具有可比性。使用组织粘合剂治疗的患者中，29%的患者视力提高到20/200或更好，而采用其他治疗方法的患者这一比例为19%。
