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饮食脂质对突触体乙酰胆碱酯酶活性的影响。

Effect of dietary lipid on synaptosomal acetylcholinesterase activity.

作者信息

Foot M, Cruz T F, Clandinin M T

出版信息

Biochem J. 1983 May 1;211(2):507-9. doi: 10.1042/bj2110507.

Abstract

The effect of dietary lipid on the thermotropic properties of acetylcholinesterase activity was examined in rat synaptosomal membrane preparations after feeding diets containing soya-bean oil, sunflower oil or soya-bean phosphatidylcholine as the dietary fats. Arrhenius plots and energies of activation were altered by the duration of feeding as a function of time, as well as by the composition of diet fat fed. Animals fed sunflower oil had the highest maximal velocity for acetylcholinesterase activity. The observations of this study suggest that dietary fat is an important determinant of the physicokinetic properties of lipid-dependent functions in brain synaptosomal membranes.

摘要

在给大鼠喂食含有大豆油、葵花籽油或大豆磷脂酰胆碱作为膳食脂肪的饲料后,研究了膳食脂质对大鼠突触体膜制剂中乙酰胆碱酯酶活性热致性质的影响。阿伦尼乌斯曲线和活化能会随喂食时间的长短以及所喂膳食脂肪的组成而改变。喂食葵花籽油的动物,其乙酰胆碱酯酶活性的最大速度最高。本研究的观察结果表明,膳食脂肪是脑突触体膜中脂质依赖性功能的物理动力学性质的重要决定因素。

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