Hacker A D, Tierney D F, O'Brien T K
Biochem Biophys Res Commun. 1983 Jun 15;113(2):491-6. doi: 10.1016/0006-291x(83)91752-7.
Ornithine decarboxylase activity increases 2-fold above control after 1 day and 25-fold after 3 days of exposure to 0.85 atm oxygen. Putrescine content nearly doubled by 72 hours which may reflect increased activity or ornithine decarboxylase. Spermidine and spermine content did not increase until after 3 days of exposure which was consistent with the delayed increase of S-adenosylmethionine decarboxylase activity. The results suggest that antimetabolites of polyamine metabolism may be useful to suppress excessive cellular proliferation in the lung after acute lung injury.
在暴露于0.85个大气压的氧气1天后，鸟氨酸脱羧酶活性比对照增加2倍，3天后增加25倍。腐胺含量在72小时内几乎翻倍，这可能反映了鸟氨酸脱羧酶活性的增加。亚精胺和精胺含量直到暴露3天后才增加，这与S-腺苷甲硫氨酸脱羧酶活性的延迟增加一致。结果表明，多胺代谢的抗代谢物可能有助于抑制急性肺损伤后肺内过度的细胞增殖。
