Iwasaki K, Ajisaka K, Iwashita Y
Biochem Biophys Res Commun. 1983 Jun 15;113(2):513-8. doi: 10.1016/0006-291x(83)91755-2.
Pyridoxylated hemoglobin was modified with the activated ester of inulin. From the oxygen equilibrium curve, this conjugate was estimated to have about fivefold oxygen carrying capacity compared with a free hemoglobin. The half disappearance time of this conjugate in the circulation of a rat was 21 hours in contrast to 3 hours of a free hemoglobin. The oncotic pressure and the viscosity can be adjusted nearly equal to those of whole blood. This conjugate can be concluded to have sufficient properties for use as a blood substitute.
吡哆醛化血红蛋白用菊粉的活性酯进行了修饰。根据氧平衡曲线估计，这种结合物的携氧能力约为游离血红蛋白的五倍。该结合物在大鼠循环中的半衰期为21小时，而游离血红蛋白为3小时。其胶体渗透压和粘度可调节至几乎与全血相等。可以得出结论，这种结合物具有足够的特性可用作血液替代品。
