雌激素对正常大鼠乳腺组织和乳腺肿瘤中超氧化物歧化酶的调节作用。

Estrogen regulation of superoxide dismutase in normal rat mammary tissues and mammary tumors.

作者信息

Whiteside C, Blackmon R H, Bremner T A

出版信息

Biochem Biophys Res Commun. 1983 Jun 29;113(3):883-7. doi: 10.1016/0006-291x(83)91081-1.

Abstract

Multiple electrophoretic molecular variants of superoxide dismutase were demonstrated in normal rat mammary tissues and DMBA-induced rat mammary tumors. The specific activities of Cu/Zu superoxide dismutase in mammary tumors of estrogen-treated rats were not significantly different from those activities seen in normal rat mammary tissues. However, the enzyme activities of mammary tumors from untreated rats (no estrogen) were significantly lower than the activities of normal rat mammary tissues. Exogenous estrogen appeared to raise superoxide dismutase levels in DMBA-induced rat mammary tumors to those levels seen in normal rat mammary tissues.

摘要

在正常大鼠乳腺组织和二甲基苯并蒽诱导的大鼠乳腺肿瘤中发现了超氧化物歧化酶的多种电泳分子变体。雌激素处理的大鼠乳腺肿瘤中铜/锌超氧化物歧化酶的比活性与正常大鼠乳腺组织中的活性无显著差异。然而，未处理大鼠（无雌激素）的乳腺肿瘤酶活性明显低于正常大鼠乳腺组织的活性。外源性雌激素似乎使二甲基苯并蒽诱导的大鼠乳腺肿瘤中超氧化物歧化酶水平升高至正常大鼠乳腺组织中的水平。