Banes A J, Yamauchi M, Mechanic G L
Biochem Biophys Res Commun. 1983 Jun 29;113(3):975-81. doi: 10.1016/0006-291x(83)91094-x.
Collagen tryptic peptides obtained from the nonmineralized and mineralized compartments of diaphyseal bone have different distributions of intermolecular crosslinks. Pyridinoline, a collagen crosslink thought to be associated with chronologically older bone, was detected in peptides from nonmineralized collagen but not from mineralized collagen. Mineralization may prevent collagen maturation; conversely, pyridinoline in nonmineralized collagen may decrease the intermolecular distances among collagen chains in fibrils and preclude mineralization.
从骨干骨的非矿化和矿化部分获得的胶原蛋白胰蛋白酶肽具有不同的分子间交联分布。吡啶啉是一种被认为与年代较久的骨相关的胶原蛋白交联物，在非矿化胶原蛋白的肽中被检测到，但在矿化胶原蛋白的肽中未被检测到。矿化可能会阻止胶原蛋白成熟；相反，非矿化胶原蛋白中的吡啶啉可能会减小原纤维中胶原链之间的分子间距离并阻止矿化。
