Uchiyama A, Inoue T, Fujimoto D
J Biochem. 1981 Dec;90(6):1795-8. doi: 10.1093/oxfordjournals.jbchem.a133657.
Pyridinoline is a non-reducible crosslink of collagen. The changes in the content of this crosslink during in vitro aging of bone collagen were studied. The pyridinoline content of bone collagen of 6-week-old chick was very low. When the collagen was incubated with physiological saline in air at 37 degrees C, the pyridinoline content increased markedly. After 6 weeks, the content reached the same level as that of the adult. The synthesis of pyridinoline was inhibited when air was excluded. The in vitro aged collagen was less susceptible to pepsin than the untreated collagen. The results indicate that pyridinoline is one of the mature crosslinks of collagen and plays a role in the stabilization of collagen fibers.
吡啶啉是胶原蛋白的一种不可还原交联物。研究了骨胶原蛋白在体外老化过程中这种交联物含量的变化。6周龄雏鸡骨胶原蛋白的吡啶啉含量非常低。当胶原蛋白在37℃空气中与生理盐水孵育时，吡啶啉含量显著增加。6周后，含量达到与成年鸡相同的水平。排除空气时，吡啶啉的合成受到抑制。体外老化的胶原蛋白比未处理的胶原蛋白对胃蛋白酶的敏感性更低。结果表明，吡啶啉是胶原蛋白的成熟交联物之一，在胶原纤维的稳定中起作用。
