去甲丙咪嗪对培养的人成纤维细胞中磷脂降解的抑制作用及磷脂模式的改变 - Suppr

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Inhibition of phospholipid degradation and changes of the phospholipid-pattern by desipramine in cultured human fibroblasts.

作者信息

Fauster R, Honegger U, Wiesmann U

出版信息

Biochem Pharmacol. 1983 Jun 1;32(11):1737-44. doi: 10.1016/0006-2952(83)90119-3.

DOI:10.1016/0006-2952(83)90119-3

PMID:6870915

Abstract

摘要

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Inhibition of phospholipid degradation and changes of the phospholipid-pattern by desipramine in cultured human fibroblasts.去甲丙咪嗪对培养的人成纤维细胞中磷脂降解的抑制作用及磷脂模式的改变

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Multisystem triglyceride storage disease is due to a specific defect in the degradation of endocellularly synthesized triglycerides.多系统甘油三酯贮积病是由于细胞内合成的甘油三酯降解存在特定缺陷所致。

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Changes in saccharide and phospholipid content associated with drug storage in cultured rabbit aorta muscle cells.培养的兔主动脉肌细胞中与药物储存相关的糖类和磷脂含量变化。

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Cholesterol and phospholipids in cultured skin fibroblasts from patients with dystonia.肌张力障碍患者培养的皮肤成纤维细胞中的胆固醇和磷脂

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Chronic exposure of human cells in culture to the tricyclic antidepressant desipramine reduces the number of beta-adrenoceptors.在培养环境中，人体细胞长期暴露于三环类抗抑郁药地昔帕明下会减少β-肾上腺素能受体的数量。

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Cytoprotection of rat hepatocytes by desipramine in a model of simulated ischemia/reperfusion.在模拟缺血/再灌注模型中地昔帕明对大鼠肝细胞的细胞保护作用。

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The persistent membrane retention of desipramine causes lasting inhibition of norepinephrine transporter function.

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Inhibition by vitamin E of drug accumulation and of phospholipidosis induced by desipramine and other cationic amphiphilic drugs in human cultured cells.维生素E对去甲丙咪嗪及其他阳离子两亲性药物在人培养细胞中诱导的药物蓄积和磷脂沉积症的抑制作用。

Br J Pharmacol. 1996 Nov;119(5):829-34. doi: 10.1111/j.1476-5381.1996.tb15747.x.

Lipidosis-like alterations in cultured macrophages exposed to local anaesthetics.暴露于局部麻醉剂的培养巨噬细胞中类似脂质沉积症的改变。

Arch Toxicol. 1984 Oct;55(4):229-32. doi: 10.1007/BF00341016.

Enhanced oxidative phosphorylation in rat liver mitochondria following prolonged in vivo treatment with imipramine.长期体内给予丙咪嗪后大鼠肝线粒体氧化磷酸化增强。

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