Erikssen J, Dale J, Rootwelt K, Myhre E
Circulation. 1983 Sep;68(3):490-7. doi: 10.1161/01.cir.68.3.490.
Latent coronary heart disease was suspected in 115 of 2014 apparently healthy middle-aged men after a baseline cardiovascular survey. One hundred five of these men underwent angiography and 36 were found to have normal coronary arteries (group 1). A 7 year follow-up survey revealed that: (1) three had died of sudden cardiac death, (2) four had received a diagnosis of cardiomyopathy, (3) one had developed aortic dilatation/aortic regurgitation since the baseline survey, (4) they all had a significantly more rapid decline in their physical performance and maximal heart rate levels from the time of the baseline survey to follow-up than did randomly selected normal controls (group 2), and (5) thallium study results were normal in both groups (27 and 26 patients), but technetium ventriculography revealed a subnormal increase in ejection fraction during exercise (less than 5% units) in 14 of 27 group 1 subjects and in 4 of 26 group 2 subjects. Thus, incipient heart disease may be present in subjects in whom coronary angiographic examination has removed a previous suspicion of coronary heart disease.
在对2014名看似健康的中年男性进行基线心血管调查后，怀疑其中115人患有潜在冠心病。这些男性中有105人接受了血管造影，发现36人冠状动脉正常（第1组）。一项为期7年的随访调查显示：（1）3人死于心源性猝死；（2）4人被诊断为心肌病；（3）自基线调查以来，1人出现主动脉扩张/主动脉反流；（4）与随机选择的正常对照组（第2组）相比，从基线调查到随访期间，他们的体能和最大心率水平下降明显更快；（5）两组（分别为27例和26例患者）的铊扫描结果均正常，但在第1组的27名受试者中有14人以及第2组的26名受试者中有4人，锝心室造影显示运动期间射血分数增加低于正常水平（小于5个百分点）。因此，在冠状动脉造影检查消除了先前对冠心病的怀疑的受试者中，可能存在早期心脏病。
