Alwmark A, Bengmark S, Gullstrand P, Idvall I, Schalén C
Eur Surg Res. 1983;15(4):217-22. doi: 10.1159/000128356.
In 82 male Sprague-Dawley rats, divided into eight groups according to surgical procedure performed (total splenectomy, sham operation and six different modes of splenic conservation), resistance to intravenous injection of 4 X 10(3) CFU of Streptococcus pneumoniae type I was evaluated 16 weeks after the surgical procedures. Significant regeneration of the spleen and almost normal resistance to pneumococci was seen 16 weeks after a two-thirds resection. Pieces of the spleen, implanted subcutaneously or into the greater omentum, also showed marked regeneration; though survival time was prolonged, the mortality among these animals following injection with pneumococci did not, however, differ from that of totally splenectomized animals. Dispersed splenic tissue, injected subcutaneously, intramuscularly, or retroperitoneally, showed less sign of regeneration and had no effect on mortality or survival time in partially vis-à-vis totally splenectomized rats.
在82只雄性Sprague-Dawley大鼠中，根据所施行的手术程序（全脾切除术、假手术以及六种不同的脾脏保留模式）分为八组，在手术操作16周后评估对静脉注射4×10³CFUⅠ型肺炎链球菌的抵抗力。三分之二脾切除术后16周可见脾脏显著再生且对肺炎球菌的抵抗力几乎正常。皮下或大网膜植入脾脏碎片也显示出明显再生；尽管生存时间延长，但这些动物注射肺炎球菌后的死亡率与全脾切除动物并无差异。皮下、肌肉内或腹膜后注射分散的脾组织再生迹象较少，对部分脾切除与全脾切除大鼠的死亡率或生存时间均无影响。
