Scher K S, Wroczynski A F, Scott-Conner C
Am Surg. 1985 May;51(5):269-71.
The effect of intraperitoneal splenic autotransplants was studied in Sprague-Dawley rats. Twenty animals underwent total splenectomy. Splenectomy was performed in another group of 20 rats, after which the spleen was diced into 15 pieces and replaced within the leaves of the small bowel mesentery. Twelve weeks later pneumococcal bacteremia was induced by intraperitoneal injection of 5 X 10(6) Streptococcus pneumoniae. Quantitative blood cultures were obtained from the tail vein 15, 30, 45, 60, 90, and 240 minutes after injection. Mean bacterial counts with time for animals bearing splenic autotransplants were not significantly different from completely asplenic rats. At autopsy, all animals receiving splenic implants were found to have viable splenic tissue among the leaves of the small bowel mesentery. This study shows that even allowing 12 weeks for maximal regeneration, splenic autotransplants fail to significantly alter the clearance of an established bacteremia.
在斯普拉格-道利大鼠中研究了腹腔内自体脾移植的效果。20只动物接受了全脾切除术。另一组20只大鼠也进行了脾切除术，之后将脾脏切成15片并置于小肠系膜叶内。12周后，通过腹腔注射5×10(6) 肺炎链球菌诱导肺炎球菌菌血症。在注射后15、30、45、60、90和240分钟从尾静脉采集定量血培养样本。接受脾自体移植的动物随时间的平均细菌计数与完全无脾的大鼠无显著差异。尸检时，发现所有接受脾植入的动物在小肠系膜叶中有存活的脾组织。这项研究表明，即使给予12周时间进行最大程度的再生，脾自体移植也未能显著改变已建立菌血症的清除情况。
