前列腺素E2（PGE2）降低冠状动脉血管阻力的特异性：与腺苷的比较。

The specificity of prostaglandin E2 (PGE2) in reducing coronary vascular resistance: A comparison with adenosine.

作者信息

Schrör K, Berg-Becker M, Nookhwun C

出版信息

Basic Res Cardiol. 1978 May-Jun;73(3):287-97. doi: 10.1007/BF01906734.

DOI:10.1007/BF01906734

Abstract

Experiments were performed on the isolated, electrically driven guinea-pig heart, perfused at constant rate. All animals were pretreated with reserpine. Myocardial contractile force (MCF), coronary perfusion pressure (CPP) and myocardial oxygen consumption (QO2) were monitored continuously. Both adenosine (ADO) and PGE2 produced a concentration-dependent decrease in the CPP. The ED50 (50% of maximum response) was 2.1 +/- 0.6 X 10(-9)M for PGE2 but 40 +/- 7 X 10(-9)M for ADO (P less than 0.01) at 1.8 mM Ca(e). This coronary vasodilation was independent of the external Ca-concentration, which was varied between 0.55-9.0 mM. PGE2 had no effect on MCF or QO2 and the effect of ADO was only slight. There was no evidence that any action of ADO could be inhibited by simultaneously applied PGE2. The results provide evidence for the specific coronary vasodilating action of PGE2 which in this system is about 20 times as effective as adenosine.

摘要

实验在以恒定速率灌注的离体电驱动豚鼠心脏上进行。所有动物均预先用利血平处理。连续监测心肌收缩力（MCF）、冠状动脉灌注压（CPP）和心肌耗氧量（QO2）。腺苷（ADO）和前列腺素E2（PGE2）均使CPP呈浓度依赖性降低。在1.8 mM Ca(e)时，PGE2的半数有效剂量（ED50，最大反应的50%）为2.1±0.6×10(-9)M，而ADO为40±7×10(-9)M（P<0.01）。这种冠状动脉舒张与外部钙浓度无关，外部钙浓度在0.55 - 9.0 mM之间变化。PGE2对MCF或QO2无影响，ADO的影响也很轻微。没有证据表明同时应用PGE2可抑制ADO的任何作用。结果为PGE2的特异性冠状动脉舒张作用提供了证据，在该系统中，PGE2的作用效果约为腺苷的20倍。