Krebs R, Schrör K
Br J Pharmacol. 1976 Aug;57(4):533-41. doi: 10.1111/j.1476-5381.1976.tb10381.x.
Left ventricular pressure (LVP), left ventricular pressure derivative (LV dp/dtmax), coronary vascular resistance (CVR) and myocardial oxygen consumption (Qo2) were measured simultaneously in isolated, electrically driven hearts of guinea-pigs at constant perfusion rate. 2 LVP, LV dp/dtmax, CVR and Qo2 were greatly decreased by either the addition of prostaglandin E2 (50 ng/ml) to the perfusion fluid or pretreatment of the animals with reserpine. 3 Isoprenaline (0.5 nM to 100 nM) induced increases in LVP, LV dp/dtmax and Qo2. In the presence of prostaglandin E2, there was a parallel shift of the isoprenaline concentration-response curve for LVP and LV dp/dtmax. This effect was not seen, after the animals had been treated with reserpine. 4 Qo2 was also decreased by prostaglandin E2 only in non-reserpine treated animals. 5 CVR was diminished by isoprenaline in the untreated group. However, there was increase in CVR, when isoprenaline was added to either prostaglandin E2 or reserpine-pretreated hearts which was enhanced in the reserpine plus prostaglandin E2-treated group (P less than 0.01). 6 The results give evidence for different actions of prostaglandin E2 on isoprenaline concentration-response curves for LVP, LV dp/dtmax and CVR.
在豚鼠离体、电驱动心脏以恒定灌注速率灌注时，同时测量左心室压力（LVP）、左心室压力变化率（LV dp/dtmax）、冠状血管阻力（CVR）和心肌耗氧量（Qo2）。2 向灌注液中添加前列腺素 E2（50 ng/ml）或用利血平预处理动物，均可使 LVP、LV dp/dtmax、CVR 和 Qo2 大幅降低。3 异丙肾上腺素（0.5 nM 至 100 nM）可使 LVP、LV dp/dtmax 和 Qo2 升高。在存在前列腺素 E2 的情况下，LVP 和 LV dp/dtmax 的异丙肾上腺素浓度 - 反应曲线出现平行位移。在用利血平处理动物后，未观察到这种效应。4 仅在未用利血平处理的动物中，前列腺素 E2 可降低 Qo2。5 在未处理组中，异丙肾上腺素可降低 CVR。然而，当将异丙肾上腺素添加到用前列腺素 E2 或利血平预处理的心脏时，CVR 会升高，在利血平加前列腺素 E2 处理组中这种升高更为明显（P 小于 0.01）。6 结果表明前列腺素 E2 对 LVP、LV dp/dtmax 和 CVR 的异丙肾上腺素浓度 - 反应曲线有不同作用。
