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Low doses of 2,4,5-trichlorophenoxyacetic acid are behaviorally teratogenic to rats.

作者信息

Crampton M A, Rogers L J

出版信息

Experientia. 1983 Aug 15;39(8):891-2. doi: 10.1007/BF01990423.

DOI:10.1007/BF01990423
PMID:6873244
Abstract

Pre-natal exposure of rats to 2,4,5-T has long-term effects on behavior. A test for novelty responding detects abnormalities after exposure to a single dose as low as 6 mg/kg on day 8 of gestation. This is well below doses reported to be morphologically teratogenic, and raises concern for human exposure.

摘要

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引用本文的文献

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Effects of prenatal exposure to 2,4-D/2,4,5-T mixture on postnatal changes in rat brain glutamate, GABA, protein, and nucleic acid levels.
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Occupational exposure and defects of the central nervous system in offspring: review.职业暴露与后代中枢神经系统缺陷：综述
Br J Ind Med. 1990 Sep;47(9):580-8. doi: 10.1136/oem.47.9.580.

本文引用的文献

1
Jumping chickens: relevance to hazard in humans.跳跃的鸡：与人类危害的相关性。
Science. 1982 Mar 12;215(4538):1422. doi: 10.1126/science.215.4538.1422.
2
2,4,5-trichlorophenoxyacetic acid causes behavioral effects in chickens at environmentally relevant doses.2,4,5-三氯苯氧乙酸在与环境相关的剂量下会对鸡产生行为影响。
Science. 1981 Feb 6;211(4482):593-5. doi: 10.1126/science.7455699.
3
Field worker exposure and helicopter spray pattern of 2,4,5-T.野外工作者接触2,4,5-涕的情况及直升机喷洒模式
Bull Environ Contam Toxicol. 1980 Jan;24(1):90-6. doi: 10.1007/BF01608080.
4
Two independent behavioral dimensions in open-field performance.旷场实验表现中的两个独立行为维度。
J Comp Physiol Psychol. 1967 Jun;63(3):500-4. doi: 10.1037/h0024620.
5
Pre- and postnatal studies on 2,4,5-trichlorophenoxyacetic acid, 2,4-dichlorophenoxyacetic acid and their derivatives in rats.
Toxicol Appl Pharmacol. 1972 May;22(1):14-28. doi: 10.1016/0041-008x(72)90221-9.
6
The open field: some comparative data.旷场实验：一些比较数据。
Ann N Y Acad Sci. 1969 Jul 30;159(3):831-51. doi: 10.1111/j.1749-6632.1969.tb12982.x.
7
Three-generation reproduction study of rats given 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the diet.
Toxicol Appl Pharmacol. 1979 Sep 15;50(2):241-52. doi: 10.1016/0041-008x(79)90149-2.