Seedorf K, Seedorf U, Pette D
FEBS Lett. 1983 Jul 25;158(2):321-4. doi: 10.1016/0014-5793(83)80605-x.
Chronic nerve stimulation induces an almost complete exchange of the fast myosin light chains (LC) LC1f and LC2f to the slow light chains LC1s and LC2s. LC3f decreases only by 30%. The exchange of the DTNB LCs (LC2f to LC2s) precedes that of LC1f to LC1s. However, the equimolar ratio of total alkali to total DTNB LCs is maintained. This points to a hitherto unknown regulation that preserves this ratio independent of whether alkali and DTNB LCs are expressed in fast or slow isotypes.
慢性神经刺激几乎可使快速肌球蛋白轻链（LC）LC1f和LC2f完全转换为慢速轻链LC1s和LC2s。LC3f仅减少30%。二硫代硝基苯甲酸（DTNB）轻链（LC2f转换为LC2s）的转换先于LC1f转换为LC1s。然而，总碱性轻链与总DTNB轻链的等摩尔比得以维持。这表明存在一种迄今未知的调节机制，可保持该比例，而与碱性轻链和DTNB轻链是以快速还是慢速同型表达无关。
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