Taylor W A, Francis D H
Int Arch Allergy Appl Immunol. 1983;72(1):79-83.
Sera of rabbits injected with Conjuvac developed high titres of pollen-specific haemagglutinating antibody. Similarly, sera of guinea pigs treated with Conjuvac developed high titres of pollen-specific IgG1 antibody, as assessed using guinea pig passive cutaneous anaphylaxis (PCA). In both species, the immunogenicity of pollen extract was increased by conjugation to alginate to an extent greater than or equal to that resulting from adsorption to aluminium hydroxide. In contrast, in rats, Conjuvac alone failed to induce pollen-specific IgE antibody, and it suppressed the IgE response induced by pollen extract absorbed to aluminium hydroxide.
注射了Conjuvac的兔子血清产生了高滴度的花粉特异性血凝抗体。同样，用Conjuvac处理的豚鼠血清产生了高滴度的花粉特异性IgG1抗体，这是通过豚鼠被动皮肤过敏反应（PCA）评估得出的。在这两个物种中，与藻酸盐结合后，花粉提取物的免疫原性增加程度大于或等于吸附到氢氧化铝后的增加程度。相比之下，在大鼠中，单独使用Conjuvac未能诱导花粉特异性IgE抗体，并且它抑制了吸附到氢氧化铝上的花粉提取物诱导的IgE反应。
