Navarro Rizo J L, Espinosa De Los Monteros Mena A, Chvarría Bonequi C
Bol Med Hosp Infant Mex. 1978 Nov-Dec;35(6):1093-107.
Blood glucose and growth hormone were measured in eight juvenile onset diabetic patients and in controls. Blood samples were obtained every 90--120 minutes for two consecutive days; in one of them, the patients received intermediate insulin, and in the other, they were also injected with additional doses of regular insulin, in order to improve their diabetic control. Normal subjects were studied in the same manner during 24 hs. without insulin. Diabetic patients showed significantly higher blood glucose and growth hormone levels when both insulins were used and only significantly higher blood glucose when they received intermediate insulin alone, than control subjects. They also showed significantly higher growth hormone and lower blood glucose levels on the day of intermediate insulin plus regular insulin than on the day of intermediate insulin. In two prebubertal controls, we observed growth hormone spurt only during sleep, while four adolescent controls showed it both while awake and asleep, as it was in all the diabetic patients we studied, including two prepubertal diabetics, one was 10 years old, and the other 13 9/12, with Turner's syndrom untreated with sexual hormones. We discuss our findings comparing with present day knowledge on this field.
对8名青少年发病的糖尿病患者和对照组进行了血糖和生长激素测量。连续两天每90至120分钟采集一次血样；其中一组患者接受中效胰岛素治疗，另一组患者还额外注射了常规胰岛素，以改善糖尿病控制情况。正常受试者在未使用胰岛素的情况下，以相同方式进行了24小时研究。与对照组相比，糖尿病患者在同时使用两种胰岛素时血糖和生长激素水平显著更高，仅使用中效胰岛素时血糖显著更高。他们在使用中效胰岛素加常规胰岛素当天的生长激素水平也显著高于使用中效胰岛素当天，而血糖水平则更低。在2名青春期前对照组中，我们观察到生长激素仅在睡眠期间出现高峰，而4名青少年对照组在清醒和睡眠时均出现生长激素高峰，我们研究的所有糖尿病患者也是如此，包括2名青春期前糖尿病患者，一名10岁，另一名13岁9/12，患有未经性激素治疗的特纳综合征。我们将我们的研究结果与该领域的现有知识进行了比较讨论。
