Ammassari-Teule M, Gozzo S, D'Udine B
Int J Neurosci. 1983 May;19(1-4):221-6. doi: 10.3109/00207458309148657.
At seven days of age, inbred strains such as SEC/Re1J and C57BL/6 present clear variations of a number of behavioral and electrophysiological parameters. The present investigation was carried out in order to provide anatomical evidence of the interstrain variability in maturation during the first postnatal week by analysing the morphological characteristics of cortical areas in seven day old SEC/Re1J and C57BL/6 mice. The somatosensory cortex was chosen on the basis of its easy localization in histological preparations, its postnatal plasticity and its functional importance during ontogeny. Different measures were performed in areas 1, 3 and 40: cortical depth, depth of layers, grey/cell coefficient, and cellular volumes. The main interstrain differences were observed in areas 1 and 40 and interpreted either in terms of ontogenic variability or, alternatively, in terms of phenotypic characteristics of the brain cortex in inbred mice. Conversely, the level of maturation in area 3 was found remarkably similar in both strains. The relationship between morphological parameters and other measures of the postnatal development is discussed.
在7日龄时，像SEC/Re1J和C57BL/6这样的近交系呈现出许多行为和电生理参数的明显差异。本研究旨在通过分析7日龄SEC/Re1J和C57BL/6小鼠皮质区域的形态学特征，为出生后第一周成熟过程中的品系间变异性提供解剖学证据。体感皮层因其在组织学标本中易于定位、出生后可塑性以及在个体发育过程中的功能重要性而被选定。在第1、3和40区进行了不同的测量：皮质深度、层深、灰质/细胞系数和细胞体积。品系间的主要差异在第1和40区被观察到，并根据个体发育变异性或近交系小鼠大脑皮质的表型特征进行了解释。相反，发现第3区的成熟水平在两个品系中非常相似。文中讨论了形态学参数与出生后发育的其他指标之间的关系。
