Book S A
Health Phys. 1983 Jul;45(1):61-6. doi: 10.1097/00004032-198307000-00006.
Irradiation of thyroid glands in rats at a dose rate of approximately 1 rad/day from continually ingested 129I resulted in no significant increase in thyroid tumors compared to controls, nor in other thyroidal effects, nor was there any difference in longevity between the two groups. Marked decreases in 131I uptake by thyroid glands of 129I-fed rats were observed, but these decreases reflected "blocking" of the thyroid by the large quantities of iodine required because of the low specific activity of 129I. In view of the lack of effects on the thyroid gland invoked by lifetime exposures to 129I, and considering the low specific activity of the radionuclide and the limited capacity of the thyroid gland for iodine, the hazard from 129I appears to be extremely limited.
以约1拉德/天的剂量率持续摄入¹²⁹I对大鼠甲状腺进行照射，与对照组相比，甲状腺肿瘤没有显著增加，也未出现其他甲状腺效应，两组大鼠的寿命也没有差异。观察到¹²⁹I喂养大鼠的甲状腺对¹³¹I的摄取显著降低，但这些降低反映了由于¹²⁹I的比活度低，甲状腺被所需的大量碘“阻断”。鉴于终生暴露于¹²⁹I对甲状腺没有影响，考虑到该放射性核素的比活度低以及甲状腺对碘的摄取能力有限，¹²⁹I的危害似乎极其有限。
