Baba M, Takeyama E, Beppu T, Jimbo M, Kitamura K
No To Shinkei. 1978 Jun;30(6):697-703.
In the previous study, quantitative analysis of RI ventriculography was reported in fifty-three cases with chronic communicating hydrocephalus. In this study, according to the same criteria as that of previous report, fifty-three cases were divided into two groups, namely NPH group (twenty-seven cases) and control group, which were considered as mere chronic communicating hydrocephalus without and NPH chalacteristics. (twenty-six cases). Results of "barrier ratio (B.R.)" measurement and regional cerebral blood flow study in these cases are as follows: 1) "Barrier ratio" using of 99mTcO4-: Concerning about B.R. of 99mTcO4- there was no significant difference between NPH and control group. However it tends to be that shunt surgery is not so effective in NPH cases in which B.R. shows abnormally low value. 2) rCBF by 133Xe clearance method: Regional cerebral blood flow was diffusely decreased in NPH patients, especially in its frontal area, suggesting the frontal area would be more severely damaged in NPH cases. These findings leads us to the conclusion that whether the shunt surgery might be effective or not depends on severity of cerebral dysfunction and the cerebral dysfunction is clearly evaluated by RI technique mentioned above.
在先前的研究中，对53例慢性交通性脑积水患者进行了放射性核素脑室造影的定量分析。在本研究中，按照与先前报告相同的标准，将53例患者分为两组，即正常压力脑积水组（27例）和对照组，后者被认为只是单纯的慢性交通性脑积水而无正常压力脑积水特征（26例）。这些病例的“屏障率（B.R.）”测量结果和局部脑血流研究结果如下：1）使用99mTcO4-的“屏障率”：关于99mTcO4-的B.R.，正常压力脑积水组和对照组之间无显著差异。然而，在B.R.显示异常低值的正常压力脑积水病例中，分流手术往往效果不佳。2）通过133Xe清除法测量的局部脑血流：正常压力脑积水患者的局部脑血流普遍减少，尤其是额叶区域，这表明在正常压力脑积水病例中额叶区域受损更严重。这些发现使我们得出结论，分流手术是否有效取决于脑功能障碍的严重程度，并且上述放射性核素技术可以清楚地评估脑功能障碍。
