磷霉素的体外抗菌活性。

Antimicrobial activity of fosfomycin in vitro.

作者信息

Forsgren A, Walder M

出版信息

J Antimicrob Chemother. 1983 May;11(5):467-71. doi: 10.1093/jac/11.5.467.

DOI:10.1093/jac/11.5.467

Abstract

Fosfomycin is a new bactericidal broad-spectrum antibiotic. In this study the minimum inhibiting concentration (MIC) was determined for 745 recent clinical isolates. Staphylococcus aureus and epidermidis, group A and B streptococci Streptococcus faecalis and pneumoniae as well as Escherichia coli, Proteus mirabilis, Serratia marcescens and Haemophilus influenzae were very sensitive to the new drug with essentially all strains inhibited at 64 mg/l or less. Klebsiella, Enterobacter, indole-positive proteus and Pseudomonas-aeruginosa were less sensitive with 96, 42, 66 and 58% inhibited at 64 mg/l of fosfomycin. Bacteroides fragilis was resistant.

摘要

磷霉素是一种新型杀菌性广谱抗生素。在本研究中，测定了745株近期临床分离菌株的最低抑菌浓度（MIC）。金黄色葡萄球菌、表皮葡萄球菌、A组和B组链球菌、粪肠球菌、肺炎链球菌以及大肠杆菌、奇异变形杆菌、粘质沙雷氏菌和流感嗜血杆菌对这种新药非常敏感，基本上所有菌株在64毫克/升或更低浓度时均被抑制。克雷伯菌属、肠杆菌属、吲哚阳性变形杆菌和铜绿假单胞菌对磷霉素的敏感性较低，在64毫克/升磷霉素浓度下，分别有96%、42%、66%和58%的菌株被抑制。脆弱拟杆菌具有耐药性。