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亚胺培南对肠球菌和葡萄球菌的体外活性以及与替考拉宁、磷霉素和利福平有高协同率的证据。

In vitro activity of imipenem against enterococci and staphylococci and evidence for high rates of synergism with teicoplanin, fosfomycin, and rifampin.

作者信息

Debbia E, Varaldo P E, Schito G C

出版信息

Antimicrob Agents Chemother. 1986 Nov;30(5):813-5. doi: 10.1128/AAC.30.5.813.

DOI:10.1128/AAC.30.5.813
PMID:2948444
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC176544/
Abstract

The in vitro activities of imipenem alone and in combination with teicoplanin, fosfomycin, and rifampin were tested against clinical isolates of enterococci and staphylococci. In both groups of organisms, the three combinations demonstrated high rates of synergism in both checkerboard and time-kill studies.

摘要

对亚胺培南单独使用以及与替考拉宁、磷霉素和利福平联合使用时针对肠球菌和葡萄球菌临床分离株的体外活性进行了测试。在这两组微生物中，这三种联合用药在棋盘法和时间杀菌研究中均显示出高协同率。

相似文献

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In vitro activity of imipenem against enterococci and staphylococci and evidence for high rates of synergism with teicoplanin, fosfomycin, and rifampin.亚胺培南对肠球菌和葡萄球菌的体外活性以及与替考拉宁、磷霉素和利福平有高协同率的证据。
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2
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本文引用的文献

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Simplified lyogroup system, a new method for routine identification of staphylococci: description and comparison with three other methods.简化的血清群系统，一种用于葡萄球菌常规鉴定的新方法：描述及与其他三种方法的比较
J Clin Microbiol. 1980 Jul;12(1):63-8. doi: 10.1128/jcm.12.1.63-68.1980.
2
Comparative in vitro activity of N-formimidoyl thienamycin against gram-positive and gram-negative aerobic and anaerobic species and its beta-lactamase stability.N-甲酰亚胺硫霉素对革兰氏阳性和革兰氏阴性需氧及厌氧菌的体外比较活性及其β-内酰胺酶稳定性
Antimicrob Agents Chemother. 1982 Jan;21(1):180-7. doi: 10.1128/AAC.21.1.180.
3
Lack of in vivo and in vitro bactericidal activity of N-formimidoyl thienamycin against enterococci.N-甲酰亚胺硫霉素对肠球菌缺乏体内和体外杀菌活性。
Antimicrob Agents Chemother. 1982 Sep;22(3):448-52. doi: 10.1128/AAC.22.3.448.
4
Antimicrobial activity of fosfomycin in vitro.磷霉素的体外抗菌活性。
J Antimicrob Chemother. 1983 May;11(5):467-71. doi: 10.1093/jac/11.5.467.
5
Synergism between N-formimidoyl thienamycin and gentamicin or tobramycin against enterococci.N-甲酰亚胺基硫霉素与庆大霉素或妥布霉素对肠球菌的协同作用。
Antimicrob Agents Chemother. 1982 Dec;22(6):1082-3. doi: 10.1128/AAC.22.6.1082.
6
In vitro evaluation of N-formimidoyl thienamycin (MK0787) combined with amikacin against gram-negative bacilli and Staphylococcus aureus.N-甲酰亚胺硫霉素（MK0787）联合阿米卡星对革兰氏阴性杆菌和金黄色葡萄球菌的体外评价
Antimicrob Agents Chemother. 1982 Dec;22(6):1064-6. doi: 10.1128/AAC.22.6.1064.
7
Susceptibility of enterococci and Listeria monocytogenes to N-Formimidoyl thienamycin alone and in combination with an aminoglycoside.肠球菌和单核细胞增生李斯特菌对单独使用及与氨基糖苷类联合使用的N-亚胺基噻烯霉素的敏感性。
Antimicrob Agents Chemother. 1981 May;19(5):789-93. doi: 10.1128/AAC.19.5.789.
8
In-vitro activity of aztreonam in combination with four other antibiotics against gram-negative bacilli and Staphylococcus aureus.氨曲南与其他四种抗生素联合对革兰氏阴性杆菌和金黄色葡萄球菌的体外活性。
J Antimicrob Chemother. 1984 Apr;13(4):398-9. doi: 10.1093/jac/13.4.398.
9
Synergism at clinically attainable concentrations of aminoglycoside and beta-lactam antibiotics.氨基糖苷类抗生素与β-内酰胺类抗生素在临床可达到浓度下的协同作用。
Antimicrob Agents Chemother. 1984 Oct;26(4):535-8. doi: 10.1128/AAC.26.4.535.
10
Imipenem antagonism of the in vitro activity of piperacillin against Pseudomonas aeruginosa.亚胺培南对哌拉西林体外抗铜绿假单胞菌活性的拮抗作用。
Antimicrob Agents Chemother. 1984 Aug;26(2):272-4. doi: 10.1128/AAC.26.2.272.